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ea0019p186 | Endocrine tumours and neoplasia | SFEBES2009

Extracellular signal-regulated kinase pathway is over-activated in pituitary adenomas

Wlodek E , Dworakowska D , Leontiou C , Igreja S , Goth M , Korbonits M , Grossman A

Background: Extracellular signal-regulated kinase (ERK) cascades are key signaling pathways involved in regulation of normal cell proliferation, survival and differentiation. Abberrant regulation of the ERK pathway contributes to tumourigenesis. The ERK signalling cascade partially controls transcription of the cell cycle regulator cyclin D1 and also expression and protein stability of the c-Myc proto-oncogene.Methods: Western Blotting was used to invest...

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ea0019p266 | Pituitary | SFEBES2009

Fifteen years experience of repeated colonoscopic screening of patients with acromegaly shows a high incidence of new colonic neoplasia and allows for effective screening guidelines

Dworakowska D , Gueorguiev M , Kelly P , Grossman AB , Monson JP , Besser GM , Chew SL , Akker S , Drake WM , Fairclough PD , Jenkins PJ

Introduction: Patients with acromegaly have an increased risk of colorectal cancer and pre-malignant adenomatous polyps; however the frequency of colonoscopic screening remains unclear.Aims: To determine optimum frequency for repeated colonoscopy of acromegalic patients.Methods: Since 1992, 254 patients (mean age 56.6 years) at our centre have undergone at least one fibre-optic colonoscopic surveillance; 156, 60 and 15 patients hav...

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Endocrine Abstracts

Extracellular signal-regulated kinase pathway is over-activated in pituitary adenomas

Fifteen years experience of repeated colonoscopic screening of patients with acromegaly shows a high incidence of new colonic neoplasia and allows for effective screening guidelines

BiosciAbstracts